Show HN: Live Feed of the HN Top 30 as an IRC Channel https://ift.tt/3rQ89bl

Show HN: Live Feed of the HN Top 30 as an IRC Channel https://ift.tt/3cIZO4Q April 4, 2021 at 04:32PM

Show HN: I made a site to explore the best UI/UX design tools out there https://ift.tt/3wtL3Lg

Show HN: I made a site to explore the best UI/UX design tools out there https://sleekui.com/ April 4, 2021 at 03:31PM

Show HN: Miniflux-CLI – offline-first Miniflux client https://ift.tt/3mi3bms

Show HN: Miniflux-CLI – offline-first Miniflux client Hey Hacker News, miniflux-cli developer here. I use miniflux as primary source of things to read (including hacker news, of course), but in my case I don't have stable internet connection most of the time, so I did offline-first console client for miniflux, check it out: https://ift.tt/3fGN40j It syncs all feeds and entries on start and after that you can read all the content offline (including "mark as read"/"mark as unread"). The project built on go, using bbolt db, tview and official miniflux api client. Some neat features - you can set text and background colors of each ui element and hide/show sidebar, statusbar and hotkeybar. Custom hotkeys will be available later, for now "vim-like" is used. April 4, 2021 at 03:20AM

Show HN: A small Clojure-like Lisp on top of R https://ift.tt/3cPBJJQ

Show HN: A small Clojure-like Lisp on top of R https://ift.tt/2tVWGgu April 4, 2021 at 03:19AM

Show HN: Advanced Algorithms Course (free to audit) https://ift.tt/3rWHFVL

Show HN: Advanced Algorithms Course (free to audit) https://ift.tt/2PVjJER April 4, 2021 at 03:15AM

Show HN: A peptide design tool for cancer vaccine https://ift.tt/39BVLFl

Show HN: A peptide design tool for cancer vaccine Dear HNers, I have coded a tool that hopefully could help oncologists to design a peptide vaccine for personalized medicine. https://ift.tt/3dxXnkF Some peptides are specific to cancers. A peptide vaccine is a way to train our body to eradicate the cells that harbor these peptides on their outer membrane. Peptide vaccines are notoriously ineffective but safe, so they could be a second line of defense against cancer after traditional drugs and therapies. A tumor develops many mutations, over time. So there is no standard medical answer. A peptide vaccine will therefore be composed of a set of peptides, which may vary over time. Because peptide vaccines can be designed very quickly, they can help respond as soon as drug resistance develops. Peptide vaccines could be a way for oncologists to distinguish themselves from their colleagues in practice, and allow them to express their know-how. This service uses its own MHC prediction service in PHP (derived from PSSMHCpan). So it is faster than NetMHCPan, but alas, it is currently hosted on a cheap VPS so it cannot take much load. I wonder if you could suggest some business model for this kind of tool? Thanks! April 4, 2021 at 02:43AM

Show HN: Modern music is slightly off tune, here is an instrument that isn't https://ift.tt/2PvZldv

Show HN: Modern music is slightly off tune, here is an instrument that isn't https://ift.tt/3fGfBmH April 4, 2021 at 01:24AM